human NSFL1C shRNA silencing Adenovirus

Name 
Ad-h-NSFL1C-shRNA
Cat No 
shADV-217113
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NSFL1C.

shADV-217113
Ad-h-NSFL1C-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NSFL1C (NSFL1 cofactor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
dJ776F14.1; NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; P47; p97 cofactor p47; SHP1 homolog; UBX domain-containing protein 2C; UBX1; UBXD10; UBXN2C
Description (eCommerce)
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of NSFL1C binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments [taken from NCBI Entrez Gene (Gene ID: 55968)].
Description (Vector)
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
Gene ID
55968
Gene Name (eCommerce)
NSFL1 cofactor
Gene Name (Vector)
NSFL1 cofactor
Gene Symbol
NSFL1C
HGNC ID
HGNC:15912
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1113
ORF Size (bp)
1113 bp
Protein Name (eCommerce)
NSFL1 cofactor p47
RefSeq ID
NM_018839
RefSeq Synonyms
NM_018839, NM_016143, NM_001206736, BC002801,
Research Areas
Golgi Apparatus,Transport
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of NSFL1C binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments [taken from NCBI Entrez Gene (Gene ID: 55968)].
UniGene ID
Hs.12865
UniProt ID (eCommerce)
Q9UNZ2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.