human NRP1 shRNA silencing Adenovirus

Name
Ad-h-NRP1-shRNA

Cat No
shADV-217095

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human NRP1.

shADV-217095

Ad-h-NRP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NRP1 (neuropilin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

BDCA4; CD304; NP1; NRP; VEGF165R

Description (Vector)

NRP1 encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene ID

8829

Gene Name (Vector)

neuropilin 1

Gene Symbol

NRP1

HGNC ID

HGNC:8004

ORF Size (aa)

1935

ORF Size (bp)

1935 bp

RefSeq ID

NM_003873

RefSeq Synonyms

NM_003873, NM_001330068, NM_001244973, NM_001244972, NM_001024629, NM_001024628, BC007737, BC007533,

Species

human

UniGene ID

Hs.714624

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.