human NPLOC4 shRNA silencing Adenovirus

Name 
Ad-h-NPLOC4-shRNA
Cat No 
shADV-216975
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NPLOC4.

shADV-216975
Ad-h-NPLOC4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
NPL4; NPLOC4 ubiquitin recognition factor; nuclear protein localization 4 homolog; nuclear protein localization protein 4 homolog; Protein NPL4
Description (eCommerce)
Nuclear protein localization protein 4 homolog (NPL4) is part of a ternary complex containing UFD1L, VCP and NPL4. The complex binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPL4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (by similarity)[taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TAT6].
Gene ID
55666
Gene Name (eCommerce)
NPL4 homolog, ubiquitin recognition factor
Gene Name (Vector)
NPL4 homolog, ubiquitin recognition factor
Gene Symbol
NPLOC4
HGNC ID
HGNC:18261
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1827
ORF Size (bp)
1827 bp
Protein Name (eCommerce)
Nuclear protein localization protein 4 homolog
RefSeq ID
NM_017921
RefSeq Synonyms
NM_017921, BC025930,
Research Areas
Golgi Apparatus,Metabolism/Metabolic Process,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Nuclear protein localization protein 4 homolog (NPL4) is part of a ternary complex containing UFD1L, VCP and NPL4. The complex binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPL4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (by similarity)[taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TAT6].
UniGene ID
Hs.464333
UniProt ID (eCommerce)
Q8TAT6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.