human NOG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NOG.
shADV-216859
Ad-h-NOG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NOG (noggin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SYM1; SYNS1; SYNS1A
Description (Vector)
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
Gene ID
9241
Gene Name (Vector)
noggin
Gene Symbol
NOG
HGNC ID
HGNC:7866
ORF Size (aa)
699
RefSeq ID
NM_005450
RefSeq Synonyms
NM_005450, BC034027,
Species
human
UniGene ID
Hs.248201
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.