human NLRP8 shRNA silencing Adenovirus

Name 
Ad-h-NLRP8-shRNA
Cat No 
shADV-216809
Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human NLRP8.

shADV-216809
Ad-h-NLRP8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NLRP8 (NLR family pyrin domain containing 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CLR19.2; NALP8; NOD16; PAN4
Description (Vector)
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)
Gene ID
126205
Gene Name (Vector)
NLR family pyrin domain containing 8
Gene Symbol
NLRP8
HGNC ID
HGNC:22940
ORF Size (aa)
3144
ORF Size (bp)
3144 bp
RefSeq ID
NM_176811
RefSeq Synonyms
NM_176811, NM_001317000, BC153174, BC148608,
Species
human
UniGene ID
Hs.446925

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.