human NLRP1 shRNA silencing Adenovirus

Name 
Ad-h-NLRP1-shRNA
Cat No 
shADV-216790
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NLRP1.

shADV-216790
Ad-h-NLRP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NLRP1 (NLR family pyrin domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; NAC; NALP1; PP1044; SLEV1; VAMAS1
Description (Vector)
NLRP1 encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Gene ID
22861
Gene Name (Vector)
NLR family pyrin domain containing 1
Gene Symbol
NLRP1
HGNC ID
HGNC:14374
ORF Size (aa)
4128
ORF Size (bp)
4128 bp
RefSeq ID
NM_014922
RefSeq Synonyms
NM_033007, NM_033006, NM_033004, NM_014922, NM_001033053, BC051787, BC016965,
Species
human
UniGene ID
Hs.652273

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.