human NF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NF2.
shADV-216623
Ad-h-NF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NF2 (neurofibromin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACN; BANF; merlin; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); Neurofibromin-2; SCH; schwannomerlin; schwannomin
Description (eCommerce)
Mutations in NF2 (neurofibromin 2) are associated with neurofibromatosis type II which is characterized by Schwann cell tumors (schwannomas) which are benign slow-growing tumors that are resistant to chemotherapeutic intervention. NF2 is a membrane/cytoskeletal associated protein that has been classified as a novel type of tumor suppressor due to its function in membrane organization versus a classic tumor suppressor function that regulates cell cycle machinery.
Description (Vector)
NF2 encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. NF2 product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. NF2 is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Gene ID
4771
Gene Name (eCommerce)
neurofibromin 2
Gene Name (Vector)
neurofibromin 2
Gene Symbol
NF2
HGNC ID
HGNC:7773
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1788
ORF Size (bp)
1788 bp
Protein Name (eCommerce)
Merlin
RefSeq ID
NM_000268
RefSeq Synonyms
NM_181833, NM_181832, NM_181831, NM_181830, NM_181829, NM_181828, NM_181825, NM_016418, NM_000268, BC020257, BC007279, BC003112,
Research Areas
Cancer,Cell Cycle,Cytoskeleton,DNA Replication,Hippo Signaling,Immunology,JAK-STAT Signaling,MAPK Signaling,Neurobiology,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Mutations in NF2 (neurofibromin 2) are associated with neurofibromatosis type II which is characterized by Schwann cell tumors (schwannomas) which are benign slow-growing tumors that are resistant to chemotherapeutic intervention. NF2 is a membrane/cytoskeletal associated protein that has been classified as a novel type of tumor suppressor due to its function in membrane organization versus a classic tumor suppressor function that regulates cell cycle machinery.
UniGene ID
Hs.187898
UniProt ID (eCommerce)
P35240
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.