human NET1 shRNA silencing Adenovirus

Name 
Ad-h-NET1-shRNA
Cat No 
shADV-216592
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NET1.

shADV-216592
Ad-h-NET1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NET1 (neuroepithelial cell transforming 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARHGEF8; epididymis secretory sperm binding protein; guanine nucleotide regulatory protein (oncogene); NET1A; neuroepithelial cell-transforming gene 1 protein; neuroepithelioma transforming gene 1; p65 Net1 proto-oncogene protein; Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor (GEF) 8; Rho guanine nucleotide exchange factor 8; small GTP-binding protein regulator
Description (eCommerce)
Neuroepithelial cell-transforming gene 1 protein (NET1) functions as a guanine exchange factor (GEF) for RhoA and plays a role in regulating apoptosis and the response to DNA damage.
Description (Vector)
NET1 is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Gene ID
10276
Gene Name (eCommerce)
neuroepithelial cell transforming 1
Gene Name (Vector)
neuroepithelial cell transforming 1
Gene Symbol
NET1
HGNC ID
HGNC:14592
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1629
ORF Size (bp)
1629 bp
Protein Name (eCommerce)
Neuroepithelial cell-transforming gene 1 protein
RefSeq ID
NM_005863
RefSeq Synonyms
NM_005863, NM_001047160, BC053553, BC010285,
Research Areas
Apoptosis,Cancer,GPCR Signaling,Neurobiology,NGF Signaling,Rho Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Neuroepithelial cell-transforming gene 1 protein (NET1) functions as a guanine exchange factor (GEF) for RhoA and plays a role in regulating apoptosis and the response to DNA damage.
UniGene ID
Hs.25155
UniProt ID (eCommerce)
Q7Z628

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.