human NEDD4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NEDD4.
shADV-216550
Ad-h-NEDD4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NEDD4 (neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; NEDD-4; NEDD4-1; Neural precursor cell expressed developmentally down-regulated protein 4; receptor-potentiating factor 1; RPF1
Description (eCommerce)
NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Independent of its ubiquitin-ligase activity, NEDD4 is involved in the pathway leading to the degradation of VEGFR-2/KDFR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P46934].
Gene ID
4734
Gene Name (eCommerce)
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene Name (Vector)
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene Symbol
NEDD4
HGNC ID
HGNC:7727
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3912
ORF Size (bp)
3912 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase NEDD4
RefSeq ID
NM_006154
RefSeq Synonyms
NM_198400, NM_006154, NM_001329212, NM_001284340, NM_001284339, NM_001284338, BC152562, BC152452, BC144285, BC144284, BC136605,
Research Areas
Antigen Processing and Presentation,Cardiovascular,Complexome,Cytokine Signaling,EGFR Signaling,Golgi Apparatus,Host-Virus Interactions,IFN Signaling,Immunology,Lysosomal Transport,Neurobiology,Neurodevelopment,Neurogenesis,Proteasome,RNA Binding,Signal Transduction,Transport,Ubiquitination,VEGF Signaling
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Independent of its ubiquitin-ligase activity, NEDD4 is involved in the pathway leading to the degradation of VEGFR-2/KDFR [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P46934].
UniGene ID
Hs.1565
UniProt ID (eCommerce)
P46934
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.