human NECAB3 shRNA silencing Adenovirus

Name
Ad-h-NECAB3-shRNA

Cat No
shADV-216543

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human NECAB3.

shADV-216543

Ad-h-NECAB3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NECAB3 (N-terminal EF-hand calcium binding protein 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

APBA2BP; dJ63M2.4; dJ63M2.5; EFCBP3; NIP1; STIP3; SYTIP2; XB51

Description (Vector)

NECAB3 interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

63941

Gene Name (Vector)

N-terminal EF-hand calcium binding protein 3

Gene Symbol

NECAB3

HGNC ID

HGNC:15851

ORF Size (aa)

1089

ORF Size (bp)

1089 bp

RefSeq ID

NM_031231

RefSeq Synonyms

NM_031232, NM_031231, BC047673,

Species

human

UniGene ID

Hs.516986

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.