human NDUFS8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NDUFS8.
shADV-216533
Ad-h-NDUFS8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CI-23k; CI23KD; CI-23kD; complex I 23kDa subunit; complex I-23kD; NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase ubiquinone iron-sulfur protein 8, mitochondrial; NADH-ubiquinone oxidoreductase 23 kDa subunit; TYKY; TYKY subunit
Description (eCommerce)
NDUFS8 is a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. NDUFS8 is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process [taken from NCBI Entrez Gene (Gene ID: 4728)].
Description (Vector)
NDUFS8 encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.
Gene ID
4728
Gene Name (eCommerce)
NADH:ubiquinone oxidoreductase core subunit S8
Gene Name (Vector)
NADH:ubiquinone oxidoreductase core subunit S8
Gene Symbol
NDUFS8
HGNC ID
HGNC:7715
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
633
Protein Name (eCommerce)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
RefSeq ID
NM_002496
RefSeq Synonyms
NM_002496, BC119754,
Research Areas
Alzheimer's Disease,Huntington's Disease,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Parkinson's Disease
Research Areas (Faceted)
neurobiology,metabolism,cell_biology
Species
human
Target Sentence
NDUFS8 is a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. NDUFS8 is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process [taken from NCBI Entrez Gene (Gene ID: 4728)].
UniGene ID
Hs.90443
UniProt ID (eCommerce)
O00217
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.