human NDUFS1 shRNA silencing Adenovirus

Name
Ad-h-NDUFS1-shRNA

Cat No
shADV-216520

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human NDUFS1.

shADV-216520

Ad-h-NDUFS1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CI-75k; CI-75Kd; PRO1304

Description (Vector)

NDUFS1 belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

4719

Gene Name (Vector)

NADH:ubiquinone oxidoreductase core subunit S1

Gene Symbol

NDUFS1

HGNC ID

HGNC:7707

ORF Size (aa)

2184

ORF Size (bp)

2184 bp

RefSeq ID

NM_005006

RefSeq Synonyms

NM_005006, NM_001199984, NM_001199983, NM_001199982, NM_001199981, BC030833, BC022368, BC012068,

Species

human

UniGene ID

Hs.471207

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.