human NBN shRNA silencing Adenovirus

Name 
Ad-h-NBN-shRNA
Cat No 
shADV-216367
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NBN.

shADV-216367
Ad-h-NBN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NBN (nibrin). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ATV; AT-V1; AT-V2; cell cycle regulatory protein p95; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; P95; p95 protein of the MRE11/RAD50 complex
Description (eCommerce)
Mutations in NBS1 (Nijmegen Breakage Syndrome 1), also known as nibrin, are associated with the autosomal recessive syndrome, Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. At the cellular level, NBS1 is part of the MRE11/RAD50 double-strand break repair complex that is critical to the DNA damage response, DNA recombination, telomere integrity, and cell cycle checkpoint control.
Description (Vector)
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Gene ID
4683
Gene Name (eCommerce)
nibrin
Gene Name (Vector)
nibrin
Gene Symbol
NBN
HGNC ID
HGNC:7652
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2262
ORF Size (bp)
2262 bp
Protein Name (eCommerce)
Nibrin
RefSeq ID
NM_002485
RefSeq Synonyms
NM_002485, NM_001024688, BC146797, BC143066, BC143065, BC136803, BC136802,
Research Areas
Apoptosis,Cancer,Cell Cycle,DNA Damage/Repair,DNA Replication,Fanconi anemia,Helicase Activity,Homologous Recombination,Meiosis,Neurobiology,Neurodevelopment,Replication,Signal Transduction,Telomeric Maintenance,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,cell_cycle,neurobiology,developmental_biology,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Mutations in NBS1 (Nijmegen Breakage Syndrome 1), also known as nibrin, are associated with the autosomal recessive syndrome, Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. At the cellular level, NBS1 is part of the MRE11/RAD50 double-strand break repair complex that is critical to the DNA damage response, DNA recombination, telomere integrity, and cell cycle checkpoint control.
UniGene ID
Hs.492208
UniProt ID (eCommerce)
O60934

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.