human MVK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MVK.
shADV-216094
Ad-h-MVK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MVK (mevalonate kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LRBP; MK; MVLK; POROK3
Description (Vector)
MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene.
Gene ID
4598
Gene Name (Vector)
mevalonate kinase
Gene Symbol
MVK
HGNC ID
HGNC:7530
ORF Size (aa)
1191
ORF Size (bp)
1191 bp
RefSeq ID
NM_000431
RefSeq Synonyms
NM_001301182, NM_001114185, NM_000431, BC016140,
Species
human
UniGene ID
Hs.130607
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.