human MTDH shRNA silencing Adenovirus

Name 
Ad-h-MTDH-shRNA
Cat No 
shADV-215975
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MTDH.

shADV-215975
Ad-h-MTDH-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MTDH (metadherin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
3D3; 3D3/LYRIC; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; protein LYRIC
Description (eCommerce)
Astrocyte elevated gene-1 protein (AEG1) is also known as metadherin. AEG1 AEG1 promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. It also promotes lung metastasis and has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. AEG1 induces chemoresistance.
Gene ID
92140
Gene Name (eCommerce)
metadherin
Gene Name (Vector)
metadherin
Gene Symbol
MTDH
HGNC ID
HGNC:29608
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
Protein Name (eCommerce)
Protein LYRIC
RefSeq ID
NM_178812
RefSeq Synonyms
NM_178812, BC045642,
Research Areas
Angiogenesis,Apoptosis,Autophagy,Cancer,NF-kB Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Astrocyte elevated gene-1 protein (AEG1) is also known as metadherin. AEG1 AEG1 promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. It also promotes lung metastasis and has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. AEG1 induces chemoresistance.
UniGene ID
Hs.377155
UniProt ID (eCommerce)
Q86UE4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.