human MSR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MSR1.
shADV-215927
Ad-h-MSR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MSR1 (macrophage scavenger receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD204; phSR1; phSR2; SCARA1; SR-A; SRA
Description (Vector)
MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Gene ID
4481
Gene Name (Vector)
macrophage scavenger receptor 1
Gene Symbol
MSR1
HGNC ID
HGNC:7376
ORF Size (aa)
1356
ORF Size (bp)
1356 bp
RefSeq ID
NM_002445
RefSeq Synonyms
NM_138716, NM_138715, NM_002445, BC063878,
Species
human
UniGene ID
Hs.147635
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.