human MLLT11 shRNA silencing Adenovirus

Name 
Ad-h-MLLT11-shRNA
Cat No 
shADV-215527
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MLLT11.

shADV-215527
Ad-h-MLLT11-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MLLT11 (myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AF1Q
Description (Vector)
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
Gene ID
10962
Gene Name (Vector)
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
Gene Symbol
MLLT11
HGNC ID
HGNC:16997
ORF Size (aa)
273
RefSeq ID
NM_006818
RefSeq Synonyms
NM_006818, BC022448, BC021703, BC019253, BC009624, BC008445, BC006471,
Species
human
UniGene ID
Hs.75823

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.