human MGAT4B shRNA silencing Adenovirus

Name
Ad-h-MGAT4B-shRNA

Cat No
shADV-215397

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human MGAT4B.

shADV-215397

Ad-h-MGAT4B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MGAT4B (mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

GNT-IV; GNT-IVB

Description (Vector)

MGAT4B encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.

Gene ID

11282

Gene Name (Vector)

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B

Gene Symbol

MGAT4B

HGNC ID

HGNC:7048

ORF Size (aa)

1647

ORF Size (bp)

1647 bp

RefSeq ID

NM_014275

RefSeq Synonyms

NM_054013, NM_014275, BC051835, BC009464,

Species

human

UniGene ID

Hs.567419

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.