human MET shRNA silencing Adenovirus

Name 
Ad-h-MET-shRNA
Cat No 
shADV-215319
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MET.

shADV-215319
Ad-h-MET-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MET (MET proto-oncogene, receptor tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AUTS9;c-Met;DFNB97;hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;HGFR;proto-oncogene c-Met;RCCP2;scatter factor receptor;SF receptor;tyrosine-protein kinase Met
Description (eCommerce)
The proto-oncogene MET is a member of the receptor tyrosine kinase family of proteins. The preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. [taken from NCBI Entrez Gene (Gene ID: 4233)].
Description (Vector)
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
4233
Gene Name (eCommerce)
MET proto-oncogene, receptor tyrosine kinase
Gene Name (Vector)
MET proto-oncogene, receptor tyrosine kinase
Gene Symbol
MET
HGNC ID
HGNC:7029
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4173
ORF Size (bp)
4173 bp
Protein Name (eCommerce)
Hepatocyte growth factor receptor
RefSeq ID
NM_000245
RefSeq Synonyms
NM_001324402, NM_001324401, NM_001127500, NM_000245, BC130420,
Research Areas
Aging,Axon Guidance,Brain Development,Cancer,Cell Cycle,EGFR Signaling,EPO Signaling,FGF Signaling,Gene Expression,Glioma,HGF Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,Neurobiology,Neurodevelopment,PI3K/Akt Signaling,Signal Transduction,Transcriptional Misregulation in Cancer,Translational Control,VEGF Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,neurobiology,developmental_biology,cell_biology,cell_cycle,signal_transduction,developmental_biology,genetics,transcription_translation,signal_transduction,immunology,cell_biology,neurobiology,developmental_biology,signal_transduction,cancer,transcription_translation,genetics,signal_transduction
Species
human
Target Sentence
The proto-oncogene MET is a member of the receptor tyrosine kinase family of proteins. The preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. [taken from NCBI Entrez Gene (Gene ID: 4233)].
UniGene ID
Hs.132966
UniProt ID (eCommerce)
P08581

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.