human MED1 shRNA silencing Adenovirus

activator-recruited cofactor 205 kDa component; ARC205; CRSP1; CRSP200; DRIP205; DRIP230; Mediator complex subunit 1; mediator of RNA polymerase II transcription subunit 1; p53 regulatory protein RB18A; PBP; peroxisome proliferator-activated receptor-binding protein; PPAR-binding protein; PPARBP; PPARGBP; RB18A; Thyroid receptor-interacting protein 2; TRAP220; TR-interacting protein 2; TRIP2; TRIP-2; vitamin D receptor-interacting protein 230 kD

MED1 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15648].

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

5469

mediator complex subunit 1

mediator complex subunit 1

MED1

HGNC:9234

9606.0

4746

4746 bp

Mediator of RNA polymerase II transcription subunit 1

NM_004774

NM_004774, BC131783, BC060758,

Angiogenesis,Apoptosis,Brain Development,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,DNA Replication,Estrogen Signaling,Gene Expression,Hedgehog Signaling,HGF Signaling,IFN Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Nuclear Receptor Coactivators,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation

human

MED1 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15648].

Hs.643754

Q15648