human MCM4 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-215185
Availability:
3-5 weeks
Name:
Ad-h-MCM4-shRNA
This is an Adenovirus expressing shRNA for silencing of Human MCM4.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- MCM4
- Gene Name
- minichromosome maintenance complex component 4
- Gene ID
- 4173
- Gene Synonyms
- CDC21; CDC54; hCdc21; NKCD; NKGCD; P1-CDC21
- ORF Size
- 2592 bp
- RefSeq#
- NM_005914
- Gene Description
- MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
- UniGene ID
- Hs.460184
- HGNC ID
- HGNC:6947
Related Products
Product | Cat No. |
---|---|
AAV-h-MCM4 | AAV-215185 |
AAV-m-MCM4 | AAV-264375 |
Ad-h-MCM4 | ADV-215185 |
Ad-m-MCM4 | ADV-264375 |
AAV-h-MCM4-shRNA | shAAV-215185 |
AAV-m-MCM4-shRNA | shAAV-264375 |
Ad-m-MCM4-shRNA | shADV-264375 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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