human MARVELD2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MARVELD2.
shADV-215045
Ad-h-MARVELD2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MARVELD2 (MARVEL domain containing 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DFNB49; MARVD2; MARVEL (membrane-associating) domain containing 2; MARVEL domain-containing protein 2; MRVLDC2; Tric; tricellulin
Description (eCommerce)
MARVELD2/Tricelluin is a component of epithelial cell tight junctions at the region where three cells come in contact with one another. It is required for the integrity and organization of tricellular contacts that form epithelial barriers. Mutations in MARVELD2/Tricellulin are associated with non-syndromic deafness.
Description (Vector)
MARVELD2 is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
153562
Gene Name (eCommerce)
MARVEL domain containing 2
Gene Name (Vector)
MARVEL domain containing 2
Gene Symbol
MARVELD2
HGNC ID
HGNC:26401
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1677
ORF Size (bp)
1677 bp
Protein Name (eCommerce)
MARVEL domain-containing protein 2
RefSeq ID
NM_001038603
RefSeq Synonyms
NM_001244734, NM_001038603, BC033689,
Research Areas
Cytoskeleton,EGFR Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
MARVELD2/Tricelluin is a component of epithelial cell tight junctions at the region where three cells come in contact with one another. It is required for the integrity and organization of tricellular contacts that form epithelial barriers. Mutations in MARVELD2/Tricellulin are associated with non-syndromic deafness.
UniGene ID
Hs.657687
UniProt ID (eCommerce)
Q8N4S9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.