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human MAP4 shRNA silencing Adenovirus

Name 
Ad-h-MAP4-shRNA
Cat No 
shADV-214945
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MAP4.

shADV-214945
Ad-h-MAP4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MAP4 (microtubule associated protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MAP-4; microtubule-associated protein 4
Description (eCommerce)
Microtubule-associated protein 4 (MAP4) is part of the structural MAP2/Tau family of microtubule-binding proteins which includes MAP2, Tau, and MAP4. MAP4 is widely-expressed in various non-neuronal tissues. However, a neural-cell specific variant generated by alternative splicing has been identified. MAP4 is multifunctional and plays a role in regulating mitotic microtubule dynamics. It associates with cyclin B1 and is regulated via its phosphorylation by cdk2.
Description (Vector)
MAP4 is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4134
Gene Name (eCommerce)
microtubule associated protein 4
Gene Name (Vector)
microtubule associated protein 4
Gene Symbol
MAP4
HGNC ID
HGNC:6862
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2940
ORF Size (bp)
2940 bp
Protein Name (eCommerce)
Microtubule-associated protein 4
RefSeq ID
NM_002375
RefSeq Synonyms
NM_030885, NM_002375, NM_001134364, BC015149, BC012794, BC008715,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Microtubule-associated protein 4 (MAP4) is part of the structural MAP2/Tau family of microtubule-binding proteins which includes MAP2, Tau, and MAP4. MAP4 is widely-expressed in various non-neuronal tissues. However, a neural-cell specific variant generated by alternative splicing has been identified. MAP4 is multifunctional and plays a role in regulating mitotic microtubule dynamics. It associates with cyclin B1 and is regulated via its phosphorylation by cdk2.
UniGene ID
Hs.517949
UniProt ID (eCommerce)
P27816

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.