human MAP3K12 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MAP3K12.
shADV-214926
Ad-h-MAP3K12-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DLK; MEKK12; MUK; ZPK; ZPKP1
Description (Vector)
MAP3K12 encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
Gene ID
7786
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 12
Gene Symbol
MAP3K12
HGNC ID
HGNC:6851
ORF Size (aa)
1704
ORF Size (bp)
1704 bp
RefSeq ID
NM_006301
RefSeq Synonyms
NM_006301, NM_001193511, BC050050,
Species
human
UniGene ID
Hs.713539
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.