human MAP2K2 shRNA silencing Adenovirus

CFC4; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; mitogen-activated protein kinase kinase 2, p45; MKK2; PRKMK2

MEK2 (MAP2K2) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MEK2 is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3, and is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development [taken from NCBI Entrez Gene (Gene ID: 5605)].

MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

5605

mitogen-activated protein kinase kinase 2

mitogen-activated protein kinase kinase 2

MAP2K2

HGNC:6842

9606.0

1203

1203 bp

Dual specificity mitogen-activated protein kinase kinase 2

NM_030662

NM_030662, BC018645, BC000471,

Amyotrophic Lateral Sclerosis (ALS),Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Bladder Cancer,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Glioma,GnRH Signaling,Golgi Apparatus,GPCR Signaling,HGF Signaling,HIF-1 Signaling,Host-Virus Interactions,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,MicroRNAs in Cancer,Mitochondrion,mTOR Signaling,Neurobiology,Neurodegeneration,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,TSLP Signaling,VEGF Signaling

cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology

human

MEK2 (MAP2K2) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MEK2 is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3, and is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development [taken from NCBI Entrez Gene (Gene ID: 5605)].

Hs.465627

P36507