human MACC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MACC1.
shADV-214768
Ad-h-MACC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MACC1 (MACC1, MET transcriptional regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
7A5; MACC1, MET transcriptional regulator; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5; SH3BP4L
Description (eCommerce)
MACC1 is a transcription activator for MET and is a key regulator of HGF-MET signaling. which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. [taken from NCBI Entrez Gene (Gene ID: 346389)].
Description (Vector)
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 (PubMed 19098908)).(supplied by OMIM, Mar 2009)
Gene ID
346389
Gene Name (eCommerce)
MET transcriptional regulator MACC1
Gene Name (Vector)
MACC1, MET transcriptional regulator
Gene Symbol
MACC1
HGNC ID
HGNC:30215
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2559
ORF Size (bp)
2559 bp
Protein Name (eCommerce)
Metastasis-associated in colon cancer protein 1
RefSeq ID
NM_182762
RefSeq Synonyms
NM_182762, BC137090,
Research Areas
Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
MACC1 is a transcription activator for MET and is a key regulator of HGF-MET signaling. which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. [taken from NCBI Entrez Gene (Gene ID: 346389)].
UniGene ID
Hs.598388
UniProt ID (eCommerce)
Q6ZN28
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.