human NBR1 shRNA silencing Adenovirus

Name 
Ad-h-NBR1-shRNA
Cat No 
shADV-214354
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NBR1.

shADV-214354
Ad-h-NBR1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NBR1 (NBR1, autophagy cargo receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
1A1-3B; B-box protein; cell migration-inducing gene 19 protein; IAI3B; M17S2; Membrane component chromosome 17 surface marker 2; membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125); MIG19; migration-inducing protein 19; neighbor of BRCA1 gene 1; Neighbor of BRCA1 gene 1 protein; next to BRCA1 gene 1 protein; Protein 1A1-3B
Description (eCommerce)
NBR1 (Next to BRCA1 gene 1 protein) was originally identified as an ovarian tumor antigen monitored in ovarian cancer.NBR1 contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. The gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene [taken from NCBI Entrez Gene (Gene ID: 4077)].
Description (Vector)
NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
Gene ID
4077
Gene Name (eCommerce)
NBR1, autophagy cargo receptor
Gene Name (Vector)
NBR1, autophagy cargo receptor
Gene Symbol
NBR1
HGNC ID
HGNC:6746
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2814
ORF Size (bp)
2814 bp
Protein Name (eCommerce)
Next to BRCA1 gene 1 protein
RefSeq ID
NM_031858
RefSeq Synonyms
NM_031862, NM_031858, NM_005899, NM_001291572, NM_001291571, BC009808,
Research Areas
Autophagy,Lysosome,MAPK Signaling,Signal Transduction,Zinc-finger
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
NBR1 (Next to BRCA1 gene 1 protein) was originally identified as an ovarian tumor antigen monitored in ovarian cancer.NBR1 contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. The gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene [taken from NCBI Entrez Gene (Gene ID: 4077)].
UniGene ID
Hs.546264
UniProt ID (eCommerce)
Q14596

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.