human FKBP5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FKBP5.
shADV-214244
Ad-h-FKBP5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FKBP5 (FK506 binding protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6; androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP51; FKBP-51; FKBP54; HSP90-binding immunophilin; P54; peptidylprolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP5; PPIase; PPIase FKBP5; Ptg-10; rotamase; T-cell FK506-binding protein
Description (eCommerce)
FKBP5/FKBP51 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP5/FKBP51 exhibits peptidyl-prolyl cis-trans isomerase activity. The most studied role of FKBP5/FKBP51 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperones Hsp90 and Hsp70, FKBP5/FKBP51 is able to influence steroid-hormone binding affinity and transcriptional activity. Recently, FKBP5/FKBP51 has become of interest in the field of psychiatry due to its potential role in cortisol regulation and its relation to mood disorders.
Description (Vector)
FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
Gene ID
2289
Gene Name (eCommerce)
FK506 binding protein 5
Gene Name (Vector)
FK506 binding protein 5
Gene Symbol
FKBP5
HGNC ID
HGNC:3721
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
Protein Name (eCommerce)
Peptidyl-prolyl cis-trans isomerase FKBP5
RefSeq ID
NM_004117
RefSeq Synonyms
NM_004117, NM_001145777, NM_001145776, NM_001145775, BC111050, BC042605,
Research Areas
Cancer,Estrogen Signaling,Prostate Cancer,Protein Folding,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology
Species
human
Target Sentence
FKBP5/FKBP51 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP5/FKBP51 exhibits peptidyl-prolyl cis-trans isomerase activity. The most studied role of FKBP5/FKBP51 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperones Hsp90 and Hsp70, FKBP5/FKBP51 is able to influence steroid-hormone binding affinity and transcriptional activity. Recently, FKBP5/FKBP51 has become of interest in the field of psychiatry due to its potential role in cortisol regulation and its relation to mood disorders.
UniGene ID
Hs.407190
UniProt ID (eCommerce)
Q13451
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.