human TBK1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TBK1.
shADV-214067
Ad-h-TBK1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TBK1 (TANK binding kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1
Description (eCommerce)
TBK1 is a member of the I-kappa-B kinase (IKK) family that plays a role in embryonic development and in the innate immune response. In response to viral infection, TBK1 activity induces transcription of genes such as IFN-gamma inducible protein (ip10), and interferon beta (ifnb). TBK1 is also implicated in the NF-kappa-B activation pathway which involves phosphorylation of I-kappaB proteins and the release and translocation of the NF-kappa-B complex to the nucleus.
Description (Vector)
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
Gene ID
29110
Gene Name (eCommerce)
TANK binding kinase 1
Gene Name (Vector)
TANK binding kinase 1
Gene Symbol
TBK1
HGNC ID
HGNC:11584
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2190
ORF Size (bp)
2190 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase TBK1
RefSeq ID
NM_013254
RefSeq Synonyms
NM_013254, BC034950,
Research Areas
Cancer,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,NF-kB Signaling,Response to Virus,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
TBK1 is a member of the I-kappa-B kinase (IKK) family that plays a role in embryonic development and in the innate immune response. In response to viral infection, TBK1 activity induces transcription of genes such as IFN-gamma inducible protein (ip10), and interferon beta (ifnb). TBK1 is also implicated in the NF-kappa-B activation pathway which involves phosphorylation of I-kappaB proteins and the release and translocation of the NF-kappa-B complex to the nucleus.
UniGene ID
Hs.607889
UniProt ID (eCommerce)
Q9UHD2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.