human LMNB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LMNB1.
shADV-214028
Ad-h-LMNB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LMNB1 (lamin B1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADLD; LMN; LMN2; LMNB
Description (Vector)
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).
Gene ID
4001
Gene Name (Vector)
lamin B1
Gene Symbol
LMNB1
HGNC ID
HGNC:6637
ORF Size (aa)
1761
ORF Size (bp)
1761 bp
RefSeq ID
NM_005573
RefSeq Synonyms
NM_005573, NM_001198557, BC103723, BC012295,
Species
human
UniGene ID
Hs.89497
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.