human LIN54 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LIN54.
shADV-213959
Ad-h-LIN54-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LIN54 (lin-54 DREAM MuvB core complex component). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CXC domain-containing protein 1; CXCDC1; JC8.6; lin-54 homolog; MIP120; protein lin-54 homolog; TCX1
Description (eCommerce)
LIN54 is a component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, LIN54 acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6MZP7].
Description (Vector)
LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 (PubMed 19725879)).(supplied by OMIM, Dec 2010)
Gene ID
132660
Gene Name (eCommerce)
lin-54 DREAM MuvB core complex component
Gene Name (Vector)
lin-54 DREAM MuvB core complex component
Gene Symbol
LIN54
HGNC ID
HGNC:25397
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1983
ORF Size (bp)
1983 bp
Protein Name (eCommerce)
Protein lin-54 homolog
RefSeq ID
NM_194282
RefSeq Synonyms
NM_194282, NM_001288997, NM_001288996, NM_001115008, NM_001115007, BC109278,
Research Areas
Cell Cycle,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
LIN54 is a component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, LIN54 acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6MZP7].
UniGene ID
Hs.96952
UniProt ID (eCommerce)
Q6MZP7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.