human LFNG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LFNG.
shADV-213843
Ad-h-LFNG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SCDO3
Description (Vector)
LFNG is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. LFNG product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
3955
Gene Name (Vector)
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene Symbol
LFNG
HGNC ID
HGNC:6560
ORF Size (aa)
753
RefSeq ID
NM_002304
RefSeq Synonyms
NM_002304, NM_001166355, NM_001040168, NM_001040167, BC014851,
Species
human
UniGene ID
Hs.159142
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.