human LDB3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LDB3.
shADV-213784
Ad-h-LDB3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LDB3 (LIM domain binding 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP
Description (Vector)
LDB3 encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
Gene ID
11155
Gene Name (Vector)
LIM domain binding 3
Gene Symbol
LDB3
HGNC ID
HGNC:15710
ORF Size (aa)
2181
ORF Size (bp)
2181 bp
RefSeq ID
NM_007078
RefSeq Synonyms
NM_007078, NM_001171611, NM_001171610, NM_001080116, NM_001080115, NM_001080114, BC111457, BC010929,
Species
human
UniGene ID
Hs.657271
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.