human LAS1L shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LAS1L.
shADV-213691
Ad-h-LAS1L-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LAS1L (LAS1 like, ribosome biogenesis factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
dJ475B7.2; Las1-like; protein LAS1 homolog; ribosomal biogenesis protein LAS1L; WTS
Description (eCommerce)
LAS1L is involved in the biogenesis of the 60S ribosomal subunit. It is required for maturation of the 28S rRNA. LAS1L functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4W2].
Gene ID
81887
Gene Name (eCommerce)
LAS1 like, ribosome biogenesis factor
Gene Name (Vector)
LAS1 like, ribosome biogenesis factor
Gene Symbol
LAS1L
HGNC ID
HGNC:25726
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2154
ORF Size (bp)
2154 bp
Protein Name (eCommerce)
Ribosomal biogenesis protein LAS1L
RefSeq ID
NM_031206
RefSeq Synonyms
NM_031206, NM_001170650, NM_001170649, BC019302, BC018610, BC014545,
Research Areas
RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
LAS1L is involved in the biogenesis of the 60S ribosomal subunit. It is required for maturation of the 28S rRNA. LAS1L functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4W2].
UniGene ID
Hs.522675
UniProt ID (eCommerce)
Q9Y4W2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.