human L1CAM shRNA silencing Adenovirus

Name 
Ad-h-L1CAM-shRNA
Cat No 
shADV-213621
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human L1CAM.

shADV-213621
Ad-h-L1CAM-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human L1CAM (L1 cell adhesion molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
antigen identified by monoclonal antibody R1; CAML1; CD antigen CD171; CD171; HSAS; HSAS1; MASA; MIC5; N-CAML1; N-CAM-L1; NCAM-L1; neural cell adhesion molecule L1; S10; SPG1
Description (eCommerce)
L1CAM/LI is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation [taken from NCBI Entrez Gene (Gene ID: 3897)].
Description (Vector)
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Gene ID
3897
Gene Name (eCommerce)
L1 cell adhesion molecule
Gene Name (Vector)
L1 cell adhesion molecule
Gene Symbol
L1CAM
HGNC ID
HGNC:6470
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3774
ORF Size (bp)
3774 bp
Protein Name (eCommerce)
Neural cell adhesion molecule L1
RefSeq ID
NM_000425
RefSeq Synonyms
NM_024003, NM_001278116, NM_001143963, NM_000425, BC136447, BC126229,
Research Areas
Apoptosis,Axon Guidance,Cardiovascular,Immunology,Neurobiology,Neurodegeneration,Neurodevelopment,Neurogenesis,Signal Transduction
Research Areas (Faceted)
cardiovascular,signal_transduction,cell_biology,neurobiology,immunology,developmental_biology
Species
human
Target Sentence
L1CAM/LI is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation [taken from NCBI Entrez Gene (Gene ID: 3897)].
UniGene ID
Hs.522818
UniProt ID (eCommerce)
P32004

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.