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human KRT8 shRNA silencing Adenovirus

Name 
Ad-h-KRT8-shRNA
Cat No 
shADV-213459
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KRT8.

shADV-213459
Ad-h-KRT8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KRT8 (keratin 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CARD2;CK8;CK-8;CYK8;cytokeratin-8;K2C8;K8;keratin 8, type II;keratin, type II cytoskeletal 8;Keratin-8;KO;type-II keratin Kb8
Description (eCommerce)
Cytokeratin 8 is a member of the type II keratin family. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cytokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells where it plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. [taken from NCBI Entrez Gene (Gene ID: 3856)].
Description (Vector)
KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Gene ID
3856
Gene Name (eCommerce)
keratin 8
Gene Name (Vector)
keratin 8
Gene Symbol
KRT8
HGNC ID
HGNC:6446
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
840
ORF Size (bp)
840 bp
Protein Name (eCommerce)
Keratin, type II cytoskeletal 8
RefSeq ID
NM_002273
RefSeq Synonyms
NM_002273, NM_001256293, NM_001256282, BC075839, BC073760, BC063513, BC008200, BC000654,
Research Areas
Cytoskeleton,EGFR Signaling,Host-Virus Interactions,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,infectious_disease
Species
human
Target Sentence
Cytokeratin 8 is a member of the type II keratin family. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cytokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells where it plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. [taken from NCBI Entrez Gene (Gene ID: 3856)].
UniGene ID
Hs.533782
UniProt ID (eCommerce)
P05787

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.