human KRT75 shRNA silencing Adenovirus

Name
Ad-h-KRT75-shRNA

Cat No
shADV-213449

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human KRT75.

shADV-213449

Ad-h-KRT75-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KRT75 (keratin 75). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

K6HF; KB18; PFB

Description (Vector)

KRT75 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. KRT75 is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS).

Gene ID

9119

Gene Name (Vector)

keratin 75

Gene Symbol

KRT75

HGNC ID

HGNC:24431

ORF Size (aa)

1656

ORF Size (bp)

1656 bp

RefSeq ID

NM_004693

RefSeq Synonyms

NM_004693, BC160175,

Species

human

UniGene ID

Hs.697046

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.