human KNTC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KNTC1.
shADV-213335
Ad-h-KNTC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KNTC1 (kinetochore associated 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hRod; HsROD; kinetochore-associated protein 1; ROD; Rough deal homolog; Rough Deal homolog, centromere/kinetochore protein
Description (eCommerce)
KNTC1 (kinetochore-associated protein 1) is the human ortholog of the drosophila rough deal (ROD) protein. Defects in the drosophila ROD protein result in chromosome missegregation. Similarly, human ROD (KNTC1) is proposed to function as a mitotic checkpoint protein present in multiprotein complexes of the kinetochore.
Description (Vector)
KNTC1 encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein.
Gene ID
9735
Gene Name (eCommerce)
kinetochore associated 1
Gene Name (Vector)
kinetochore associated 1
Gene Symbol
KNTC1
HGNC ID
HGNC:17255
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6630
ORF Size (bp)
6630 bp
Protein Name (eCommerce)
Kinetochore-associated protein 1
RefSeq ID
NM_014708
RefSeq Synonyms
NM_014708, BC150278,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
KNTC1 (kinetochore-associated protein 1) is the human ortholog of the drosophila rough deal (ROD) protein. Defects in the drosophila ROD protein result in chromosome missegregation. Similarly, human ROD (KNTC1) is proposed to function as a mitotic checkpoint protein present in multiprotein complexes of the kinetochore.
UniGene ID
Hs.300559
UniProt ID (eCommerce)
P50748
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.