human KLRC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KLRC1.
shADV-213320
Ad-h-KLRC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KLRC1 (killer cell lectin like receptor C1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD159a;CD159 antigen-like family member A;CD159A;C-lectin type II protein;killer cell lectin-like receptor subfamily C, member 1;natural killer cell lectin;natural killer group protein 2;NK cell receptor A;NKG2;NKG2-1/B activating NK receptor;NKG2A;NKG2-A/B type II integral membrane protein;NKG2-A/B-activating NK receptor;NKG2-A/NKG2-B type II integral membrane protein
Description (eCommerce)
NKG2A belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The NKG2 family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2A forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. [provided by RefSeq, Jan 2015] [taken from NCBI Entrez Gene (Gene ID: 3821)].
Description (Vector)
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
Gene ID
3821
Gene Name (eCommerce)
killer cell lectin like receptor C1
Gene Name (Vector)
killer cell lectin like receptor C1
Gene Symbol
KLRC1
HGNC ID
HGNC:6374
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
648
Protein Name (eCommerce)
NKG2-A/NKG2-B type II integral membrane protein
RefSeq ID
NM_002259
RefSeq Synonyms
NM_213658, NM_213657, NM_007328, NM_002259, NM_001304448, BC053840, BC012550,
Research Areas
Antigen Processing and Presentation,Immunology
Research Areas (Faceted)
immunology
Species
human
Target Sentence
NKG2A belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The NKG2 family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2A forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. [provided by RefSeq, Jan 2015] [taken from NCBI Entrez Gene (Gene ID: 3821)].
UniGene ID
Hs.512576
UniProt ID (eCommerce)
P26715
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.