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human KIF22 shRNA silencing Adenovirus

Name 
Ad-h-KIF22-shRNA
Cat No 
shADV-213087
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KIF22.

shADV-213087
Ad-h-KIF22-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KIF22 (kinesin family member 22). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
94
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A-328A3.2; KID; Kinesin-like DNA-binding protein; kinesin-like DNA-binding protein pseudogene; kinesin-like protein 4; kinesin-like protein KIF22; KNSL4; OBP; OBP-1; OBP-2; origin of plasmid DNA replication-binding protein; oriP binding protein; SEMDJL2
Description (eCommerce)
The kinesin superfamily of proteins consists of forty five KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis.  Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments.  KIF22/KID has been demonstrated to be required for proper chromosome alignment at the metaphase plate as well as spindle formation.
Description (Vector)
KIF22 is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
3835
Gene Name (eCommerce)
kinesin family member 22
Gene Name (Vector)
kinesin family member 22
Gene Symbol
KIF22
HGNC ID
HGNC:6391
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1998
ORF Size (bp)
1998 bp
Protein Name (eCommerce)
Kinesin-like protein KIF22
RefSeq ID
NM_007317
RefSeq Synonyms
NM_007317, NM_001256270, NM_001256269, BC028155, BC004352,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Chromatin Remodeling,Cytoskeleton,DNA Damage/Repair,Immunology
Research Areas (Faceted)
immunology,cell_biology,cell_cycle,transcription_translation,genetics
Species
human
Target Sentence
The kinesin superfamily of proteins consists of forty five KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis.  Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments.  KIF22/KID has been demonstrated to be required for proper chromosome alignment at the metaphase plate as well as spindle formation.
UniGene ID
Hs.613351
UniProt ID (eCommerce)
Q14807

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.