human RPTOR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RPTOR.
shADV-212993
Ad-h-RPTOR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RPTOR (regulatory associated protein of MTOR complex 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KOG1; Mip1; p150 target of rapamycin (TOR)-scaffold protein; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats; raptor; regulatory-associated protein of mTOR
Description (eCommerce)
Raptor (regulatory-associated protein of mTOR) is part of the rapamycin sensitive mTORC1 complex which includes mTOR, and mLst8/GbetaL. S6K and 4EBP1 are substrates of mTORC1 kinase activity. Raptor is required for mTOR’s ability to phosphorylate 4E-BP1 and physically interacts with 4EBP1 to act as a potential scaffold that bridges mTOR and 4EBP1 or S6K. The mTORC1 complex integrates cell signals to promote cell growth in response to growth factors.
Description (Vector)
RPTOR encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
57521
Gene Name (eCommerce)
regulatory associated protein of MTOR complex 1
Gene Name (Vector)
regulatory associated protein of MTOR complex 1
Gene Symbol
RPTOR
HGNC ID
HGNC:30287
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4008
ORF Size (bp)
4008 bp
Protein Name (eCommerce)
Regulatory-associated protein of mTOR
RefSeq ID
NM_020761
RefSeq Synonyms
NM_020761, NM_001163034, BC136654, BC136652, BC064515,
Research Areas
Cancer,Cardiovascular,Cell Cycle,HGF Signaling,IFN Signaling,IGF-1 Signaling,Insulin Signaling,LKB1 Signaling,Lysosome,MicroRNAs in Cancer,mTOR Signaling,Neurobiology,PI3K/Akt Signaling,Prostate Cancer,RNA Binding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Raptor (regulatory-associated protein of mTOR) is part of the rapamycin sensitive mTORC1 complex which includes mTOR, and mLst8/GbetaL. S6K and 4EBP1 are substrates of mTORC1 kinase activity. Raptor is required for mTOR’s ability to phosphorylate 4E-BP1 and physically interacts with 4EBP1 to act as a potential scaffold that bridges mTOR and 4EBP1 or S6K. The mTORC1 complex integrates cell signals to promote cell growth in response to growth factors.
UniGene ID
Hs.133044
UniProt ID (eCommerce)
Q8N122
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.