human KDELR2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KDELR2.
shADV-212830
Ad-h-KDELR2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ELP-1; ERD2.2
Description (Vector)
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
11014
Gene Name (Vector)
KDEL endoplasmic reticulum protein retention receptor 2
Gene Symbol
KDELR2
HGNC ID
HGNC:6305
ORF Size (aa)
561
RefSeq ID
NM_006854
RefSeq Synonyms
NM_006854, NM_001100603, BC071982, BC012994, BC008081,
Species
human
UniGene ID
Hs.705873
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.