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human KCNA5 shRNA silencing Adenovirus

Name 
Ad-h-KCNA5-shRNA
Cat No 
shADV-212655
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KCNA5.

shADV-212655
Ad-h-KCNA5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KCNA5 (potassium voltage-gated channel subfamily A member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ATFB7; HCK1; HK2; HPCN1; KV1.5; PCN1
Description (Vector)
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).
Gene ID
3741
Gene Name (Vector)
potassium voltage-gated channel subfamily A member 5
Gene Symbol
KCNA5
HGNC ID
HGNC:6224
ORF Size (aa)
1842
ORF Size (bp)
1842 bp
RefSeq ID
NM_002234
RefSeq Synonyms
NM_002234, BC099666, BC099665, BC096358, BC096357,
Species
human
UniGene ID
Hs.150208

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.