Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human JPH1 shRNA silencing Adenovirus

Name 
Ad-h-JPH1-shRNA
Cat No 
shADV-212590
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human JPH1.

shADV-212590
Ad-h-JPH1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human JPH1 (junctophilin 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CMT2K; JP1; JP-1; junctophilin type 1; junctophilin-1
Description (eCommerce)
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. Junctophlin 1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HDC5].
Description (Vector)
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
Gene ID
56704
Gene Name (eCommerce)
junctophilin 1
Gene Name (Vector)
junctophilin 1
Gene Symbol
JPH1
HGNC ID
HGNC:14201
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1986
ORF Size (bp)
1986 bp
Protein Name (eCommerce)
Junctophilin-1
RefSeq ID
NM_020647
RefSeq Synonyms
NM_020647, NM_001317830, BC140876, BC140875,
Research Areas
Transport
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. Junctophlin 1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HDC5].
UniGene ID
Hs.657367
UniProt ID (eCommerce)
Q9HDC5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.