human ITGA2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ITGA2.
shADV-212474
Ad-h-ITGA2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ITGA2 (integrin subunit alpha 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
alpha 2 subunit of VLA-2 receptor; BR; CD antigen CD49b; CD49 antigen-like family member B; CD49B; collagen receptor; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA-2 subunit alpha; VLAA2
Description (eCommerce)
Integrin alpha-2 is product of the gene ITGA2 (aka CD49B). Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. This receptor mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia [taken from NCBI Entrez Gene (Gene ID: 3673) and UniProtKB (Entry: P17301)].
Description (Vector)
ITGA2 encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. ITGA2 is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
Gene ID
3673
Gene Name (eCommerce)
integrin subunit alpha 2
Gene Name (Vector)
integrin subunit alpha 2
Gene Symbol
ITGA2
HGNC ID
HGNC:6137
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3543
ORF Size (bp)
3543 bp
Protein Name (eCommerce)
Integrin alpha-2
RefSeq ID
NM_002203
RefSeq Synonyms
NM_002203, BC156715, BC148596,
Research Areas
Axon Guidance,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,Host-Virus Interactions,Immunology,Interleukin Signaling,Lung Cancer,Neurobiology,PI3K/Akt Signaling,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Integrin alpha-2 is product of the gene ITGA2 (aka CD49B). Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. This receptor mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia [taken from NCBI Entrez Gene (Gene ID: 3673) and UniProtKB (Entry: P17301)].
UniGene ID
Hs.482077
UniProt ID (eCommerce)
P17301
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.