human IPO4 shRNA silencing Adenovirus

Name
Ad-h-IPO4-shRNA

Cat No
shADV-212345

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human IPO4.

shADV-212345

Ad-h-IPO4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IPO4 (importin 4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

No

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Imp4; imp4b; importin-4; importin-4b; ran-binding protein 4; ranBP4

Description (eCommerce)

Importin 4 mediates the nuclear import of RPS3A. In vitro, it mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Additionally, along with importin 7, importin 4 has been shown to be involved in nuclear import of HIF-1alpha [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q8TEX9].

Gene ID

79711

Gene Name (eCommerce)

importin 4

Gene Name (Vector)

importin 4

Gene Symbol

IPO4

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3246

ORF Size (bp)

3246 bp

Protein Name (eCommerce)

Importin-4

RefSeq ID

NM_024658

RefSeq Synonyms

NM_024658, BC136759, BC110804,

Research Areas

Immunology,Signal Transduction,Transport

Research Areas (Faceted)

signal_transduction,immunology,cell_biology

Species

human

Target Sentence

Importin 4 mediates the nuclear import of RPS3A. In vitro, it mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Additionally, along with importin 7, importin 4 has been shown to be involved in nuclear import of HIF-1alpha [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q8TEX9].

UniGene ID

Hs.411865

UniProt ID (eCommerce)

Q8TEX9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.