human INF2 shRNA silencing Adenovirus

Name 
Ad-h-INF2-shRNA
Cat No 
shADV-212259
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human INF2.

shADV-212259
Ad-h-INF2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human INF2 (inverted formin, FH2 and WH2 domain containing). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C14orf151; C14orf173; CMTDIE; FSGS5; HBEAG-binding protein 2 binding protein C; HBEBP2-binding protein C; inverted formin-2; pp9484
Description (eCommerce)
Inverted formin-2 (INF2) is a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that human INF2 may function in polymerization and depolymerization of actin filaments. Mutations in the INF2 gene have been associated with focal segmental glomerulosclerosis 5 [taken from NCBI Entrez Gene (Gene ID: 64423)].
Description (Vector)
INF2 represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.
Gene ID
64423
Gene Name (eCommerce)
inverted formin, FH2 and WH2 domain containing
Gene Name (Vector)
inverted formin, FH2 and WH2 domain containing
Gene Symbol
INF2
HGNC ID
HGNC:23791
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3750
ORF Size (bp)
3750 bp
Protein Name (eCommerce)
Inverted formin-2
RefSeq ID
NM_032714
RefSeq Synonyms
NM_032714, NM_022489, NM_001031714, BC172394, BC006173,
Research Areas
Cytoskeleton,Neurobiology,Neurodegeneration,Neurodevelopment
Research Areas (Faceted)
cell_biology,neurobiology,developmental_biology
Species
human
Target Sentence
Inverted formin-2 (INF2) is a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that human INF2 may function in polymerization and depolymerization of actin filaments. Mutations in the INF2 gene have been associated with focal segmental glomerulosclerosis 5 [taken from NCBI Entrez Gene (Gene ID: 64423)].
UniGene ID
Hs.24956
UniProt ID (eCommerce)
Q27J81

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.