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human ILF2 shRNA silencing Adenovirus

Name 
Ad-h-ILF2-shRNA
Cat No 
shADV-212224
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ILF2.

shADV-212224
Ad-h-ILF2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ILF2 (interleukin enhancer binding factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
interleukin enhancer binding factor 2, 45kD; interleukin enhancer binding factor 2, 45kDa; interleukin enhancer-binding factor 2; NF45; Nuclear factor of activated T-cells 45 kDa; nuclear factor of activated T-cells, 45-kDa; PRO3063
Description (eCommerce)
The 45kDa nuclear factor of activated T-cells (NF45) functions as part of a heterodimeric complex with NF90 to form the transcription factor, NFAT (nuclear factor of activated T-cells). The NF45/NF90 complex binds the interleukin-2 promoter and regulates transcription of the IL2 gene during T-cell activation. It has also been shown that the NF45/NF90 complex can function as a negative regulator of miRNA biogenesis.
Description (Vector)
ILF2 is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14.
Gene ID
3608
Gene Name (eCommerce)
interleukin enhancer binding factor 2
Gene Name (Vector)
interleukin enhancer binding factor 2
Gene Symbol
ILF2
HGNC ID
HGNC:6037
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1173
ORF Size (bp)
1173 bp
Protein Name (eCommerce)
Interleukin enhancer-binding factor 2
RefSeq ID
NM_004515
RefSeq Synonyms
NM_004515, NM_001267809, BC000382,
Research Areas
B-cell Receptor Signaling,Immunology,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
The 45kDa nuclear factor of activated T-cells (NF45) functions as part of a heterodimeric complex with NF90 to form the transcription factor, NFAT (nuclear factor of activated T-cells). The NF45/NF90 complex binds the interleukin-2 promoter and regulates transcription of the IL2 gene during T-cell activation. It has also been shown that the NF45/NF90 complex can function as a negative regulator of miRNA biogenesis.
UniGene ID
Hs.75117
UniProt ID (eCommerce)
Q12905

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.