human IL1B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IL1B.
shADV-212090
Ad-h-IL1B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IL1B (interleukin 1 beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IL-1; IL1-BETA; IL1F2
Description (Vector)
IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Gene ID
3553
Gene Name (Vector)
interleukin 1 beta
Gene Symbol
IL1B
HGNC ID
HGNC:5992
ORF Size (aa)
810
ORF Size (bp)
810 bp
RefSeq ID
NM_000576
RefSeq Synonyms
NM_000576, BC008678,
Species
human
UniGene ID
Hs.126256
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.