Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human IGF2BP3 shRNA silencing Adenovirus

Name 
Ad-h-IGF2BP3-shRNA
Cat No 
shADV-211921
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IGF2BP3.

shADV-211921
Ad-h-IGF2BP3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cancer/testis antigen 98; CT98; hKOC; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; IMP3; IMP-3; insulin-like growth factor 2 mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; KOC; KOC1; VICKZ family member 3; VICKZ3
Description (eCommerce)
Insulin-like growth factor 2 mRNA-binding protein 3 (IMP3) is an RNA-binding protein that act as a regulator of mRNA translation and stability. IMP3 binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs and to sequences in the 3'-UTR of CD44 mRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O00425].
Description (Vector)
IGF2BP3 is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
Gene ID
10643
Gene Name (eCommerce)
insulin like growth factor 2 mRNA binding protein 3
Gene Name (Vector)
insulin like growth factor 2 mRNA binding protein 3
Gene Symbol
IGF2BP3
HGNC ID
HGNC:28868
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1740
ORF Size (bp)
1740 bp
Protein Name (eCommerce)
Insulin-like growth factor 2 mRNA-binding protein 3
RefSeq ID
NM_006547
RefSeq Synonyms
NM_006547, BC065269, BC051296,
Research Areas
Gene Expression,mRNA Binding,mRNA transport,RNA Binding,RNA Processing,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Insulin-like growth factor 2 mRNA-binding protein 3 (IMP3) is an RNA-binding protein that act as a regulator of mRNA translation and stability. IMP3 binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs and to sequences in the 3'-UTR of CD44 mRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O00425].
UniGene ID
Hs.700696
UniProt ID (eCommerce)
O00425

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.